ABSTRACT
Gut microbiota plays an important role in digestive system diseases and has been paid more and more attention.Chronic pancreatitis is a common clinical disease of digestive system, its pathogenesis is not completely clear.Gastrointestinal microflora dysbiosis is associated with many pancreatic diseases.Similarly, the occurrence of chronic pancreatitis is related to the gut microbiota dysbiosis, and the intestinal microecological balance is broken, resulting in varying degrees of gastrointestinal microflora dysbiosis and bacterial translocation, which affects the occurrence and development of chronic pancreatitis.This review analyzes the changes of gut microbiota in chronic pancreatitis and the possible pathogenesis, so as to provide a reference for discussing the clinical value of gut microbiota in the diagnosis and treatment of chronic pancreatitis.